A gruesome display of corpses on the frozen Thames spells doom for Mycroft Holmes.Scotland Yard singles him out as the main suspect of a series of violent crimes, because they're all connected by a single thread: Mycroft's name. As public attention rises, he fights to avert any danger to his family and the Secret Service.To capture the culprit, Mycroft has to face an exceedingly uncomfortable truth about himself, which puts not only his career, but his very life into question.
Sherlock Holmes is missing. Dr. Watson receives a cursed note, summoning him to the city of Milan. In his plight, he turns to the one person who can help him: Mycroft Holmes, secret agent and eternally concerned elder brother. Mycroft has to team up with Dr. Watson and fellow agent Victoria Trevor to follow Sherlock's trail and stand against the dark forces that threaten his life.